The present investigation on performance of N, P and K on growth, yield and quality of watermelon (citrullus lanatus Thunb.) cv. Kiran under South Suarashtra condition was carried out at Fruit Research Station, Deptt. of Horticulture, Junagadh Agric. Univ., Junagadh during the year 2010. The experiment was laid out in R.B. Design with Factorial concept (FRBD). In all there were 16 treatment combinations with 1 control treatment, which were assigned at random in each plots within replications such as a treatments in which three levels of Nitrogen (N1: 50, N2: 75, N3: 100 & N4 : 125 kg/ha), two levels of Phosphorus (P1 : 75 & P2 : 100) and two levels of Potassium (K1 : 40 & K2 : 60 kg/ha). The results of experiment reveal that growth characters such as number of branches per plant, number of nodes per plant, length of main axis and intermodal length were significantly influenced by higher dose of nitrogen (125 kg/ha). Number of branches and nodes per plant were also found significant differences due to levels of phosphorus and significant differences were observed in number of branches per plant and length of main axis due to different levels of potash. Whereas, significantly minimum values for growth characters were recorded under the control treatment. The yield attributing characters such as fruit length, number of fruits per plants and average fruit weight were significantly increased with increasing level of nitrogen (0 to 125 kg/ha). Similarly yield attributing characters increased with increasing level of potash (0 to 60 kg/ha). Characters like fruit length and average fruit weight were increased significantly with higher dose of phosphorus. Yield of fruit per plant and per hectare were registered maximum under higher dose of nitrogen (125 kg/ha) and potash (60 kg/ha) while, lower yield recorded by control. Quality characters like pulp weight, TSS, reducing sugar and total sugar were also significantly increased with increasing level of nitrogen and phosphorus application, but non-significant differences were observed due to different level of potassium application except in pulp weight of fruit.