An experiment was conducted to study the potential of Chlorella minutissima to remove the nutrient and heavy metals from the sewage wastewater of Indian Agricultural Research Institute (IARI). Samples collected from sewage water stream from IARI field at two months intervals and characterized for physicochemical characteristics. C. minutissima was grown in sewage water at different dilutions in plastic trays under controlled conditions. The response of C. minutissima in the wastewater was measured by analyzing the growth by taking the optical density of wastewater at different times. The accumulation of free nutrients, salts and other chemical elements by C. minutissima was measured by again characterizing the residual wastewater. The difference between the first and second depiction gives the estimate of pollutant accumulation by microalgae. The outcome of research had suggested the potential of specific microalgae to reduce the BOD, COD and pollution load of the sewage wastewater of IARI. The experiment has also revealed the ability of C. minutissima to reduce the total dissolved solids (TDS) of sewage water. The initial TDS value of sewage wastewater was in the range of 1900 to 2900 ppm and after the phycoremediation by C. minutissima, it is reduced to the range of 30 to 100 ppm. Hence, C. minutissima could be used for the remediation of sewage wastewater due to potential ability to reduce the TDS and pollution load and can further utilize for the safe irrigation of crops at IARI fields. The resulting biomass of microalgae can then collected and valued, in particular for biodiesel production, which will be the objective of the future study.