In this study, the physical and chemical properties of three locally grown pomegranate fruit cultivars relevant for post-harvest handling and processing were determined. Significant differences in fruit size and skin colour, aril size and colour, juice content and titrable acidity were found among the cultivars. The fruit weight, fruit length, fruit diameter, skin thickness, aril percentage, and juice percentage were within the range of 235.10-292.64 g, 59.04-75.09 mm, 75.9-86.2 mm, 2.85-4.70 mm, 26.3-61.9%, and 60.08-64.6%, respectively. Total soluble solid content varied from 14.08 to 15.77°Brix, pH values from 3.34 to 3.66, titratable acidity from 0.24 to 0.37 g/100 g fresh weight, total sugars content from 11.3 to 14.88 g/100 g fresh weight, total anthocyanins content from 15.53 to 27.73 mg/100 g fresh weight, ascorbic acid from 9.78 to 12.21 mg/100 g fresh weight, and total phenolics from 289.4 to 454.63 mg/100 g fresh weight. The antioxidant activity of pomegranate juice, as determined by the 1,1-diphenyl-2-picrylhydrazyl assays, was between 46.03 and 72.97%. These results demonstrated that the cultivar is the main factor determining the physico-chemical properties and antioxidant activities in pomegranates.