This study aim was to evaluate soybean cultivars for their reaction (relative susceptibility and resistance), effect of different inoculum levels and comparative efficacy of plant pesticides and nematicide against root-knot nematode. Out of twenty five varieties / germplasm, two BRAGG and JS 73 -22 gave very resistance reactions whereas, PK-472, NRC-2 and JS20-34 found highly susceptible at inoculum level was 1000 N per pot to root-knot nematode (M. incognita). Effects of different levels of M. incognita on growth parameters of soybean. Pots inoculated with the highest level i.e.10000 nematode / pot exhibited severe stunting with large galls. The progressive level of inoculation showed stunted in shoot weight, decreased foliage number, reduced fresh and dry shoot and root weight and root length. Many plants have shown identified bearing nematicidal activity attributable to allelochemicals accumulated in tissues or synthesized during a process of secondary metabolism. Chemical control of plant-parasitic root-knot nematodes essentially, involves the use of synthetic nematicides. However, carbofuran was highly effective against the root-knot management. It is investigated that Jatropha inhibited the hatching of root knot nematode due to have some special chemical properties. Jatropha cake @ 2 ton / ha gave good management enhanced plant growth and reproductive parameters as well as increase the mortality of juveniles and egg masses.