The investigation was undertaken to study the influence of seed treatment with micronutrients (Zn and B), bio-fertilizers (Azotobacter and PSB) and pesticides (Imidacloprid) on nutrient uptake, yield and economics of sunflower (Helianthus annuus L.) at Zonal Agricultural Research Station (AICRP on Sunflower scheme), GKVK, University of Agricultural Sciences, Bengaluru during kharif-2013. The experiment consists of fifteen treatments laid out in Randomised Complete Block Design with three replications. Treatments include application of micronutrients through different methods like soil application, foliar application and seed treatment in combination with bio-fertilizers and pesticide as individual application and in combinations along with RDF (90:90:60 kg NPK ha-1). The field study indicated that, total uptake of macro nutrients (N, P, K and S) did not responded to seed treatment with micronutrients, bio-fertilizers and pesticides significantly but biofertilizer application increased the micro nutrient uptake compared to non-biofertilizer application treatments. Combined application of micronutrient (B), bio-fertilizers and pesticides through seed treatment in addition to RDF improved the seed yield (15.35 %) and oil yield (15.97 %) of sunflower (KBSH-53) significantly compared to soil application of micronutrients and control. Also recorded lower cost of cultivation and better BCR (2.10) compared to RDF alone (1.70), acts as alternate option to improve the economic yield with minimum cost.