An experiment comprised of six male sterile lines and 10 inbred testers of pearl millet and their 60 hybrids was conducted at the Department of Agricultural Botany, Research Farm, College of Agriculture, Latur, M.K.V., Parbhani, Maharastra, India during 2010-2011 for studying the extent of hybrid vigour in F1 for grain yield and it's components. Highest and significant positive relative heterosis, heterobeltiosis and standard heterosis was observed in the cross MS-94555 A x 268 R for grain yield per plant and the same combination showed positive relative heterosis, heterobeltiosis and standard heterosis for the number of effective tillers per plant. The cross combination MS-98222 A x 1358 R showed higher magnitude of positive relative heterosis and standard heterosis for the trait total number of tillers. Highest and significant positive heterobeltiosis was recorded in MS-841 A x UCC-23 R for total number of tillers. The hybrid cross combination MS-841 A x 1358 R showed highest and significant relative heterosis, heterobeltiosis and standard heterosis for 1000 grains weight. The hybrid MS-863 A x 1404 R recorded highest and significant positive standard heterosis for ear head girth and number of grains per cm2, MS-94555 A x 122 R for ear head length. 13 hybrids recorded highly significant standard heterosis for grain yield per plant among 60 hybrids. Ten hybrids namely MS-98222 A x 1358 R, MS-88004 A x 1358 R, MS-88004 A x 418 R, MS-841 A x UCC-23 R, MS-841 A x 1358 R, MS-841 A x 1404 R, MS-94555 A x 268 R, MS-863 A x UCC-23 R, MS-863 A x 260 R, MS-863 A x 1404 R, were selected as best crosses since they expressed high mean performance and high standard heterosis over check hybrids RHRBH-9808 and AHB-1666 for most of the traits studied.