Field experiment were conducted during rabi and kharif season of 2012 and 2013 at Cotton Research Station, Veppantattai, to study the effect of tillage and weed management methods on weeds dynamics and yield of maize –sunflower cropping system under irrigated conditions. The experiments were laid out in strip plot design with three replications. Main plot treatment consisted of three tillage methods viz., conventional tillage, minimum tillage and zero tillage. Five weed management methods viz., pre-emergence application of herbicide (atrazine @ 0.5 kg ha-1 for maize and pendimenthalin @1.0 kg ha-1 for sunflower) followed by hand weeding on 40 DAS, pre- emergence application of herbicide (atrazine @ 0.5 kg ha-1 for maize and pendimenthalin @ 1.0 kg ha-1 for sunflower) followed by power weeding on 40 DAS, hand weeding twice on 20 and 40 DAS, Power weeding on 20 and 40 DAS along with an unweeded check for both the crops consisted the sub plot treatments. The maize seeds of NK 6240 and sunflower hybrid seed sunbred were sown on 60 x 25 cm. spacing. Recommended fertilizer dose of 250:75:75 kg NPK/ha for maize and 60: 30: 30 kg NPK / ha for sunflower were applied in the form of urea, single super phosphate and muriate of potash. The results revealed that conventional tillage combined with pre-emergence herbicide application (atrazine @ 0.5 kg ha-1 for maize and pendimethalin @ 1.0 kg ha-1 for sunflower) followed by hand weeding on 40 DAS recorded lower weed density and dry weight and higher weed control efficiency , yield and net return and benefit cost ratio .