A field experiment was conducted at Agricultural Research Station, Warangal during kharif, 2011 to evaluate yield, nutrient uptake and soil moisture extraction under different crops and intercropping systems in rainfed alfisols. Cotton, redgram, castor, maize, greengram, groundnut were sown as sole crops and then cotton and castor were intercropped with greengram where as redgram and maize were intercropped with both greengram and groundnut. The density of intercrop component was 66 per cent in cotton, redgram, castor and 50 per cent in maize. Soil analysed after harvest of the crops and intercropping systems, revealed that nitrogen was significantly influenced whereas phosphorus and potash were unaffected. Maximum nitrogen depletion (189 kg ha-1) was noticed with sole maize and minimum with sole groundnut (276 kg ha-1). The soil had relatively more moisture content in 30 cm depth than 15 cm depth throughout the crop period Sole crops recorded more yield and the reduction in seed cotton yield was 12.77, redgram 6.60, castor 5.56 and maize 2.3 per cent when intercropped with greengram, whereas with groundnut intercropping maize yielded 96.9 per cent and redgram 92.1 per cent of their respective sole crop yields. Equivalent seed cotton yield of 2310 kg ha-1 was realized from cotton + greengram intercropping which was at par with redgram + greengram ( 2216 kg ha-1) and significantly superior over other sole and intercropping systems.